NLRP3 and colitis: Furthermore, activated nuclear factor-erythroid factor 2-related factor 2 (Nrf2), the primary regulator of the antioxidant response (Bellezza et al., 2018), can inhibit the assembly of the NLR family pyrin domain containing 3 (NLRP3) inflammasome, thereby preventing dextran sulfate sodium (DSS)-induced colitis (Ahmed et al., 2017).