NLRP3 inflammasome is responsible for increased production of IL-1β (Iida et al., 2020), and suppressing NLRP3 inflammasome activation by inhibiting MKP1/NF-κB pathway could attenuate DSS-induced ulcerative colitis (Wei et al., 2021). The gene discussed is NFKB1; the disease is ulcerative colitis.