c-Myc expression was significantly increased in myeloid leukemia cell lines and primary acute myeloid leukemia (AML) cells compared with PBMCs of normal subjects (Figure 2B), and matrine inhibited the expression of c-Myc and proliferation of myeloid leukemia and primary AML cells more significantly (Figures 2C,D). The gene discussed is MYC; the disease is myeloid leukemia.