Through published literature retrieval, we found that among the common pathways, MAPK pathway, PI3K-Akt pathway and PD-L1 expression and PD-1 checkpoint pathway in cancer had the highest correlation with lung cancer; therefore, we selected MAPK pathway, PI3K-Akt pathway, and PD-L1 expression and PD-1 checkpoint pathway in cancer to elaborate the detailed mechanism of LGT and JQC in the treatment of LC. The gene discussed is CD274; the disease is laryngotracheoesophageal cleft.