These include: MAPK signaling pathway, PI3K-Akt signaling pathway, cAMP signaling pathway, PD-L1 expression and PD-1 checkpoint pathway in cancer, Rap1 signaling pathway, etc. JQC pathways covered 42 pathways of LGT toxicity targets, including IL-17 signaling pathway, Fluid Sheet Stress and Atherosclerosis, and Human cytomegalovirus infection. The gene discussed is PIK3CA; the disease is atherosclerosis.