CA12 and non-small cell lung carcinoma: In addition, among common targets of LGT and JQC, a series of carbonic anhydrase such as CA12, CA2, CA1, and CA9 are also highly expressed, and published evidence shown that carbonic anhydrase can affect the proliferation of non-small cell lung cancer (NSCLC) through the Wnt/β-catenin signaling pathway (Wang et al., 2020a).