PIK3CA and lung carcinoma: First, genes of LGT were enriched in 194 pathways, genes of lung cancer were enriched in 180 pathways, and related genes in GTC were enriched in 225 pathways, among which there were 137 common pathways, the more significant ones were MAPK signaling pathway, PI3K-Akt signaling pathway, HIF-1 signaling pathway, cAMP signaling pathway, etc. In JQC, genes were enriched along 145 pathways, while toxicity targets for LGT were enriched along 69 pathways.