AKT3 and lung cancer: The targets of JQC components were distributed downstream of the comprehensive signaling pathway, like RAF1; As for the component targets of LGT, they are present both upstream and downstream of the comprehensive signaling pathway, for example, PIK3CA, AKT3, MAP3K3, etc. This result fully demonstrated that LGT and JQC exert synergistic therapeutic effect on lung cancer by targeting different genes in the comprehensive signaling pathway as well as the common component targets.