Reportedly, in an acetaminophen-induced acute liver failure mouse model, both LPS-TLR4 pathway therapies reduced cell death, increased renal function, and decreased the coma-free survival rate (Shah et al., 2013), suggesting that the LPS-TLR4 axis is implicated in inflammatory processes that lead to tissue damage, and blocking this signaling pathway stops disease development. This evidence concerns the gene TLR4 and acute liver failure.