Pan et al. (2021) demonstrated the liver-protective effects of Shenling Baizhu San against inflammatory damage through TLR4/NLRP3 signaling in rats with NAFLD. In this study, 23 main compounds from six herbs were obtained; these herbs might target 3,132 of the 8,096 ACLF disease targets via expression profile analysis. This evidence concerns the gene TLR4 and metabolic dysfunction-associated steatotic liver disease.