TWEAK/Fn14-promoted cell migration and/or invasiveness have been reported for various tumor cell lines in vitro, including glioblastoma cells, NSCLC, ovarian cancer cells, breast cancer cell lines and androgen-independent prostate cancer cells (Tran et al., 2003; Willis et al., 2008; Dai et al., 2009; Huang et al., 2011; Lin et al., 2012; Whitsett et al., 2012; Asrani et al., 2013; Whitsett et al., 2014; Cheng et al., 2015; Jandova et al., 2015; Armstrong et al., 2016; Wang et al., 2018; Hu et al., 2019; Li et al., 2019). This evidence concerns the gene TNFRSF12A and prostate cancer.