A549 cells overexpressing Fn14 showed enhanced lung metastasis upon tail vein injection in mice (Whitsett et al., 2012) and H460 tumor cells over-expressing Fn14 showed more metastases in lung, liver and lymph nodes compared to mice challenged with H460 cells with low Fn14 levels (Jandova et al., 2015). Here, TNFRSF12A is linked to neoplasm.