Similarly, it has been demonstrated that RhoA and the RhoA-specific GEF Src homology 3 domain-containing guanine nucleotide exchange factor (SGEF) mediate TWEAK-induced cell migration in the glioma cell lines U87 and U118 (Fortin Ensign et al., 2013). The gene discussed is TNFSF12; the disease is central nervous system cancer.