In line with these findings, the guanine nucleotide exchange factors (GEFs) Ect2 and Trio, which promote the conversion of Cdc42 and Rac1 to their GTP-bound active state, have been crucially involved in TWEAK-induced cell migration in the T98G glioma cell line (Fortin et al., 2012). Here, TNFSF12 is linked to central nervous system cancer.