Accordingly, it has been reported that TWEAK induces activation of the non-receptor tyrosine kinase Lyn and that the knockdown of the latter abrogates TWEAK-induced chemotactic migration in T98A and A172 glioma cells as well as Rac1 activation (Dhruv et al., 2014). The gene discussed is TNFSF12; the disease is central nervous system cancer.