In line with these findings, the guanine nucleotide exchange factors (GEFs) Ect2 and Trio, which promote the conversion of Cdc42 and Rac1 to their GTP-bound active state, have been crucially involved in TWEAK-induced cell migration in the T98G glioma cell line (Fortin et al., 2012). This evidence concerns the gene RAC1 and glioma.