Furthermore, both pro-apoptotic protein proteins (Cleaved caspase 9, Cleaved PARP, Bax) and mRNA (Caspase 9, Bax) levels were significantly increased in a dose-dependent manner in melanoma cells, whereas anti-apoptotic protein and mRNA level of Bcl2 was decreased sharply (Figure 5A–C). This evidence concerns the gene CASP9 and melanoma.