Alternative splicing of the PKM gene to skip exon 9 and include exon 10 generates PKM2 in cancer cells through hnRNP A1/A2 binding to UAGGG at 5’ SS in intron 9 and hnRNP I interacting with two UCUUC in intron 8 (Clower et al., 2010). The gene discussed is PKM; the disease is cancer.