3,5-diCQA pretreatment significantly inhibited TMT-induced disruption of the cholinergic neurotransmission and cognitive impairment by increasing acetylcholine (ACh) levels and decreasing acetylcholinesterase (AChE) activity in the brain tissue of ICR mice compared to negative controls (Kang et al., 2016). Here, ACHE is linked to Cognitive impairment.