Investigation on apoptotic effects of Withaferin A in human renal carcinoma Caki cells also note inhibition of STAT3 activation, inhibition of JAK2 phosphorylation, suppression of STAT3 regulated genes and its related anti-apoptotic proteins such as, survivin, Bcl-2, and Bcl-xl (Um et al., 2012). Here, STAT3 is linked to renal carcinoma.