HE staining indicated that although medium and high doses of Nephropathy 1st could relieve the degree of renal fibrosis, the therapeutic effect was abrogated by GW9662 treatment, as evidenced by the results that rats from the GW9662 group showed severe inflammatory cell infiltration and high expression of collagen III and α-SMA even after Nephropathy 1st administration. The gene discussed is ACTA1; the disease is Nephropathy.