CAT and diabetic kidney disease: In diabetic kidney disease, resveratrol showed protective effects by improving the levels of antioxidant enzymes such as superoxide dismutase (SOD), glutathione peroxidase (GPx), catalase (CAT) and levels of vitamin C and E. Further, RSV treatment upregulated the level of NrF2 and its downstream targets (glutamyl cysteine synthetase, heme oxygenase-1) in the renal tissue (Li et al., 2005; Castrejón-Tellez et al., 2016).