SIRT1 signaling has been associated with aging, caloric intake, and immune responses, and consistently, SIRT1 has also been associated with various age-associated diseases such as neurodegenerative diseases (Chen et al., 2020), type II diabetes (Karbasforooshan and Karimi, 2018), and immune-associated diseases (Yu et al., 2018). Here, SIRT1 is linked to neurodegenerative disease.