IL6 and gout: IL-1β is a key proinflammatory cytokine in the inflammatory response of gout, and the mechanism of its proinflammatory effect may be to induce the release of other inflammatory cytokines (e.g., IL-6 and IL-8) through a complex signaling cascade effect, thereby synergistically promoting the occurrence of gout (So and Martinon, 2017; Narang and Dalbeth, 2020; Dalbeth et al., 2021).