Li et al. (2021a) confirmed that miR-221-5p interacts with the 3′ UTR of IL-1β and can target and inhibit IL-1β. An and Yin (2021) verified that miR-192-5p regulates the pathogenesis of GA by targeting EREG protein and inhibiting the activation of M1 macrophages. Jin et al. (2014) found that the miR-155/SHIP-1 pathway leads to upregulation of IL-1β and TNF-α. However, Yang et al. (2018) recently found that miR-155 may be unimportant in MSU-induced gout inflammation in mice, and deletion of miR-155 may not alleviate acute gout inflammation. The gene discussed is IL1B; the disease is gout.