Furthermore, NF-κB inhibition by administration of withaferin A alleviated disease symptoms in TDP-43 mice (Swarup et al., 2011) and extended lifespan of SOD1(G93A) and SOD1(G37R) mouse models of ALS (Frakes et al., 2014; Patel et al., 2015). Here, TARDBP is linked to amyotrophic lateral sclerosis.