It is worth noting that, in an effort to target different ALS mechanisms, some of the described HDAC inhibitors have been already successfully tested in combination with other molecules, including riluzole (Del Signore et al., 2009), the catalytic antioxidant AEOL 10150 (Petri et al., 2006), and the mood stabilizer lithium (Feng et al., 2008). Here, HDAC9 is linked to amyotrophic lateral sclerosis.