RELA and ischemia: Neurotoxic stimuli, including ischemia (Inta et al., 2006), glutamate (Pizzi et al., 2002), β-amyloid (Pizzi et al., 2005), or 1-methyl-4-phenylpyridinium (MPP+) (Ghosh et al., 2007; Sarnico et al., 2008) induce the activation of p50/RelA dimer and the transcription of pro-apoptotic factors, such as Bim and Noxa.