In particular, a specific pro-apoptotic acetylation profile of nuclear RelA, involving the general deacetylation of lysines but a site-specific acetylation at the lysine 310 [acRelA(K310)], occurs in lethal ischemia but not in protective preconditioning brain ischemia (Lanzillotta et al., 2010). This evidence concerns the gene RELA and brain ischemia.