Oridonin is derived from the plant Rabdosia Rubescens, reduces lactate output by inducing AMPK inactivation, significantly downregulates GLUT1 and MCT1 protein levels in all six CRC cell lines and SW480 xenograft tumors, inhibits glucose uptake in cancer cells resulting in metabolic imbalance, and induces autophagy (Fujita et al., 1976; Yao et al., 2017). Here, SLC2A1 is linked to colorectal carcinoma.