β-Escin is a natural pentacyclic triterpenoid saponin derived from the seed of Aesculus hippocastanum L. It has been found in studies to limit the lowering of HIF-1α-targeted proteins, LDHA, CD31, and HK2 in ovarian cancer (OvCa) mouse omentum, therefore inhibiting OvCa invasion (Cheong et al., 2018; Kenny et al., 2021). Here, HK2 is linked to ovarian cancer.