Flavonoids: In gastric cancer cells (AGS), baicalein attenuated the expression of HIF-1α by regulating the PTEN/Akt/HIF-1α signaling pathway, inhibited the process of glycolysis in tumor cells, and reversed the hypoxia-induced 5-FU drug resistance (Chen et al., 2015). This evidence concerns the gene AKT1 and neoplasm.