Others: By directly binding to PKM2 in prostate cancer cells (DU145), 2′-hydroxycinnamaldehyde (HCA) induced PKM2 to exist in a tetrameric form with strong PK activity and inhibited PKM2-mediated STAT3 phosphorylation, limiting cell proliferation in vitro and tumor growth in vivo (Yoon et al., 2018). This evidence concerns the gene PKM and Familial prostate cancer.