Tanshinone IIA, the main component of Danshen (Salvia miltiorrhiza Bunge), was confirmed by Li et al. (2020a) to promote the E3 ligase FBW7-mediated ubiquitination and degradation of c-Myc by inhibiting the Akt-c-Myc signaling pathway, ultimately reducing the expression of HK2 has become one of the potential anti-oral squamous cell carcinoma drugs. The gene discussed is MYC; the disease is squamous cell carcinoma.