HIF1A and breast carcinoma: Epigallocatechin (EGC) was reported to speed up the protease degradation of HIF-1α in MCF-7 and MDA-MB-231 cells by interfering with the interaction of heat shock protein (Hsp90) with HIF-1α, according to in vitro and in vivo investigations on breast cancer by Wang et al. (2013b).