Emodin and rhein are anthraquinone components derived from Rheum palmatum that can inhibit HIF-1α and diminish the downstream glucose regulating molecules, GLUT1, as well as reduce the expression of HK2 and PFK1 and prevent the Warburg Effect of human pancreatic cancer cells (Hu et al., 2017). Here, HK2 is linked to familial pancreatic carcinoma.