HK2 and neoplasm: Terpenoids: Oleanolic acid (OA) inhibited tumor growth in human gastric cancer cells (MKN-45 and SGC-7901) by decreasing HK2 and PFK1 expression and intracellular activity, as well as decreasing HIF-1α expression and nuclear abundance, hence reduced glycolysis and induced cell apoptosis (Li et al., 2019b).