Shikonin suppressed tumor promoter 12-O-tetradecanoylphorbol 13-acetate (TPA) caused tumor cell transformation and PKM2 activation in early stages of carcinogenesis in Skin Epidermal JB6 Cells, showing the chemopreventive potential of PKM2-for human skin cancer (Li et al., 2014). The gene discussed is PKM; the disease is skin cancer.