Graviola, which is extracted from Annona Muricata, could inhibit glucose uptake in pancreatic cancer cells by suppressing the expression of HIF-1α, NF-κB, GLUT1/GLUT4, HK2 and LDHA according to a recent study, thereby decrease ATP generation (Torres et al., 2012). This evidence concerns the gene HK2 and pancreatic neoplasm.