Quercetin could reduce the acidity of the tumor microenvironment by inhibiting the glycolysis-related proteins expression of PKM2, GLUT1 and LDHA in MCF-7 and MDA-MB-231 cells, thus inhibiting glucose uptake and lactate production (Jia et al., 2018; Barbosa and Martel, 2020). This evidence concerns the gene LDHA and neoplasm.