GSDME and head and neck cancer: Triptolide (TPL), a natural diterpenoid epoxide derived from a traditional Chinese herb, reduced the expression of c-myc and mitochondrial HK2 in head and neck cancer cells and activated the BAD/BAX-caspase 3-GSDME cascade, triggering GSDME-mediated pyroptosis (Cai et al., 2021).