B16F10 cells may manufacture Jolkinolide B (JB), a bioactive diterpenoid isolated from the root of Euphorbia fischeriana Steud, by down-regulating the mRNA expression of glycolysis-related genes HK2 and LDHA and glucose transporters GLUT1, GLUT3, and GLUT4, promoting melanoma cell apoptosis (Gao et al., 2016). This evidence concerns the gene SLC2A1 and melanoma.