In HCT116 Cells, wogonin inhibited the expression of HIF-1α and glycolysis-related proteins (HK2, PDHK1, LDHA) by inhibiting the PI3K/Akt signaling pathway, reduced glucose uptake and lactate production to combat drug resistance of tumor cell (Wang et al., 2014). The gene discussed is AKT1; the disease is neoplasm.