Apigenin could effectively downregulate HIF-1α and GLUT-1 mRNA and protein expression in human pancreatic cancer S2-013 and CD18 cells, and overcome any hypoxia-mediated elevation of GLUT-1 gene expression, thereby suppressing aerobic glycolysis and promoting tumor cell apoptosis (Melstrom et al., 2011). Here, ITGB2 is linked to familial pancreatic carcinoma.