Dauricine (Dau), another alkaloid, was found to efficiently decrease HK2 and PKM2 gene expression in hepatocellular carcinoma HCC cells by increasing the expression of miR-199a, hence increasing the chemosensitivity of HCC cells to some chemotherapy medicines like cisplatin and sorafenib (Li et al., 2018a). Here, HK2 is linked to hepatocellular carcinoma.