The polyphenol extract can dose-dependently inhibit p-PI3K, p-Akt expression, promote p-ERK1/2, p-JNK and p-38 MAPK expression, and exert anti-tumor effect by regulating PI3K/Akt and MAPKs pathways (Park et al., 2012). The gene discussed is AKT1; the disease is neoplasm.