Relevant studies (Berretta et al., 2019; Liu et al., 2022) have found that basic fibroblast growth factor (bFGF) and vascular endothelial growth factor (VEGF) are body-specific angiogenic factors that can create favorable conditions for the invasion and metastasis of cancer cells, and both bFGF and VEGF are involved in the progression of HCC. This evidence concerns the gene FGF2 and cancer.