Moreover, since inflammatory responses play an important role in cerebral ischemia/reperfusion injury, several studies further explored the effect of triptolide on NF-kB, an essential regulator of inflammatory responses, in MCAO, and reported the inhibitory effect of triptolide on NF-kB activity (Jin et al., 2015; Bai et al., 2016a; Bai et al., 2016b). The gene discussed is NFKB1; the disease is brain ischemia.