PSEN1 and Alzheimer disease: Beside that, a study found that in the amyloid precursor protein/presenilin 1 (APP/PS1) double transgenic AD murine model, peripherally administered triptolide improved cognitive function, accompanied by reduced neuroinflammation and Aβ deposition, and that reduction of Aβ deposition may be associated with enhanced Aβ degradation (Cheng et al., 2014).