A recent study proposed that celastrol mixed in regular feed could reduce the accumulation of neurofibrillary tangles in the brains of two common animal models of AD (P301S microtubule associated protein tau mice and 3XTg mice) by activating transcription factor EB-mediated autophagy and lysosome biogenesis, thereby attenuating memory deficits in AD mice. The gene discussed is TFEB; the disease is Alzheimer disease.