In addition, BAP1, KEAP1, KRAS and ARF can downregulate SLC7A11 through NRF2 or NRF2-independent pathways (Chen et al., 2017; Dodson et al., 2019; Lim et al., 2019; Hu et al., 2020) and thus promote tumor metabolism. Here, SLC7A11 is linked to neoplasm.