The top 20 were IL6, AKT1, VEGFA, TNF, CCL2, IL1B, EGF, CASP3, CXCL8, MAPK1, MMP9, EDN1, PTGS2, NOS3, SERPINE1, IL10, TP53, EGFR, ICAM1, and MMP2, which suggested that these proteins might play a key role in the treatment of CHD with HXQR. This evidence concerns the gene NOS3 and coronary artery disorder.