F11 and Venous thrombosis: Genomic studies show that individuals with genetic defects in FXIa do not have spontaneous bleeding, and high levels of FXI are closely related to coronary artery diseases such as venous thrombosis and myocardial infarction; On the contrary, FXI deficiency does not have a great impact on physiological hemostasis (Key, 2014; Georgi et al., 2019; Wang et al., 2021).