At the same time, there were significant differences in C-C chemokine receptor type 2 (CCR2) and Tumor necrosis factor-α (TNF-α) in preoperative plasma and liver between NASH patients and non-NASH patients, so it is considered that the improvement of liver fibrosis involves the regulation of oxidative stress and inflammation levels. The gene discussed is TNF; the disease is metabolic dysfunction-associated steatohepatitis.