Another study shows that suppression of HDAC11 enhances the prevention of pyroptosis in human umbilical vein endothelial cells (HUVECs) triggered by TNF-α, indicating that vascular endothelial pyroptosis might be prevented through downregulation of HDAC11 related signaling pathways in atherosclerosis (AS) (101). Here, HDAC11 is linked to atherosclerosis.