CD4 and type 1 diabetes mellitus: Looking in the pancreas, we found that despite comparable frequencies of total CD4+ T cells (Supplementary Figure 4E), central memory (CM; CD44hiCD62L+) (Supplementary Figure 4G) and naïve (Supplementary Figure 4H) CD4+ T cells, we observed a reduced frequency of EM cells (Supplementary Figure 4F) in mice receiving Ins+alum, which may account for the reduced T1D incidence recorded in this group.