Given the mechanisms underlying the differences among different groups, we investigated the association between drug sensitivity and expression of GRGs in prostate cancer based on the GDSC and CTRP databases, and observed that GNPDA1, TPST1, GPC1, PYGB, B4GALT1 and ALDOA were positively correlated with the IC50 of most drugs, while ANKZF1, SAP30 and STMN1 were mainly negatively correlated (Figures 8A, B). The gene discussed is TPST1; the disease is Familial prostate cancer.