BMI (odds ratio [OR], 1.37; 95% confidence interval [CI], 1.020–1.842; P<0.005), basal LH level (OR, 1.19; 95% CI, 1.021–1.382; P<0.005), and uterine diameter (OR, 2.65; 95% CI: 0.982-7.143; P=0.05) were significantly related to the diagnosis of precocious puberty, whereas basal E2 level and ovarian volume were not (Table 4). This evidence concerns the gene PLOD1 and precocious puberty.