Programmed cell death with a necrotic appearance is called necroptosis and occurs in several biological processes, including inflammation, the immunological response and metabolic disorders (10).,RIPK1 (receptor-interacting protein kinase 1), RIPK3 (receptor-interacting protein kinase 3), and MLKL (mixed-lineage kinase domain-like pseudokinase) play an important role in this process (11). The gene discussed is MLKL; the disease is Other metabolic disease.