•CHD (80%)•Bleeding disorders (30%-65%)•Intrinsic pathway abnormalities (50%)•Abnormal electrocardiographic pattern (50%)•PS (40%)•Factor deficiencies (FVIII, FXI, FXII), platelet defects (33%)•HCM (20%)•Atrioventricular canal defects (15%)•Atrial septal defect (6%-10%)•Left-sided obstructive lesions. The gene discussed is F11; the disease is atrial septal defect.