In addition, circulating corin was also significantly increased in the pregnant woman with hypertension and preeclampsia.33, 34, 35 In the Gusu cohort, our group has examined and found that serum corin was significantly and positively associated with major risk factors of CVD, such as hypertension,19 diabetes,36,37) dyslipidemia,38 and obesity.39 The gene discussed is CORIN; the disease is obesity due to melanocortin 4 receptor deficiency.