Adding serum corin to the prediction model did not significantly increase prediction performance for CVD events (AUC: 0.746 vs 0.744; P = 0.625), stroke (AUC: 0.796 vs 0.792; P = 0.652), or CHD (AUC: 0.729 vs 0.728; P = 0.707) compared with the model including conventional risk factors only (Supplemental Figure 2). This evidence concerns the gene CORIN and coronary artery disorder.