CD4 and infection: In advanced HIV/AIDS patients with CD4+T cell counts of less than 200 cells/ul, the risk of infection with T. marneffei was significantly increased, the same as other pathogens (such as Mycobacterium tuberculosis, Cryptococcus, and Pneumocystis jirovecii) (Jiang et al., 2019; Qin et al., 2020), and the risk of mixed infections was also increased.