EIF4E3 and cancer: What’s more, the expression of some writer genes (METTL1 and WDR4) and reader genes (AGO2 and NCBP2) was significantly upregulated in most cancers, while the expression of some eraser genes (NUDT12 and NUDT16) and some reader genes (EIF4E3) were downregulated in most cancers (Figure 2E).