For example, METTL1, a m7G methyltransferase, its aberrant upregulation in tumors has been found to be linked to end-stage tumors and worse prognosis, and METTL1 can drive oncogenic transformation and accelerate tumor progression by promoting m7G tRNA modification (Chen et al., 2021; Ma et al., 2021; Orellana et al., 2021). The gene discussed is METTL1; the disease is neoplasm.