The top 10 mutated regulators across cancers were EIF4G3, CYFIP1, GEMIN5, LARP1, AGO2, NCBP1, NUDT12, EIF3D, DCP2, and EIF4A1 with the mutation frequency of 22%, 17%, 15%, 15%, 14%, 12%, 7%, 7%, 6%, and 6% respectively. This evidence concerns the gene AGO2 and cancer.