AKT1 and ovarian cancer: In ovarian cancer, BTG1 expression caused lower growth rate, high cisplatin sensitivity, G1 arrest, apoptosis, and decreased migration and invasion by down-regulating the expression of PI3K (phosphatidylinositol 3-kinase), PKB (protein kinase B), Bcl-xL, survivin, VEGF (vascular epithelial growth factor), and MMP (matrix metalloproteinase)-2 (Zhao et al., 2013).