CD274 and non-small cell lung carcinoma: Previously, a number of studies have made investigations on this topic and revealed that TMB, PD-L1, and tumor-infiltrating lymphocytes derived from core biopsy specimens were correlated with immunotherapy prognosis of NSCLC (Kerr et al., 2015; Meng et al., 2015; High TMB Predicts Immunotherapy Benefit, 2018).