Knockdown of lncRNA SBF2-AS1 in exosomes produced by M2 macrophages promotes miR-122-5p expression and decreases XIAP levels, indicating lncRNA SBF2-AS1 could inhibit apoptosis by modulating XIAP via miR-122-5p in pancreatic cancer (Yin et al., 2020). Here, XIAP is linked to familial pancreatic carcinoma.