Under the heterozygous genotype model, the association of VDBP gene rs7041 polymorphism with COPD was potentiated in Caucasians (OR: 0.16, 95% CI: 0.03 to 0.97, p = 0.046), in studies with matched patients and controls (OR: 0.19, 95% CI: 0.06 to 0.58, p = 0.004), in studies with doctor-diagnosed COPD (OR: 0.01, 95% CI: 0.00 to 0.10, p < 0.001), and adopting ATS criteria (OR: 0.44, 95% CI: 0.23 to 0.85, p = 0.014). The gene discussed is GC; the disease is chronic obstructive pulmonary disease.