First, using the limma package to perform differential analysis of CRGs in the four GEO cohorts PD and control, respectively (Figures 1A–D), we found that DLD, DLAT, and DBT were differentially expressed in GSE7621, NFE2L2, DLD, MTF1, GLS, DLAT, PDHA1, PDHA1, and LIPT1 were differentially expressed in GSE8397. Here, GLS is linked to Parkinson disease.