CALR and osteosarcoma: Previous studies have shown that CALR is associated with various diseases, such as myeloproliferative neoplasms (MPNs) (Klampfl et al., 2013; Nangalia et al., 2013), neuroblastoma (Hsu et al., 2005), colorectal carcinoma (Peng et al., 2010), non-small cell lung carcinoma (NSCLC) (Fucikova et al., 2016), acute myeloid leukemia (AML) (Schardt et al., 2009), osteosarcoma (Zhang et al., 2017), and glioblastoma (Muth et al., 2016).