However, there is a soluble form of MICA (sMICA) that decreases the expression and presentation of NKG2D, a natural cytotoxic receptor in natural killer cells, thus sMICA helps cancer cells to evade immune cell attack (Pan et al., 2017) and contributing to a worse prognosis in cancer (Roshani et al., 2016). Here, MICA is linked to cancer.