HK2 and urothelial carcinoma: To further improve the sensitivity of UETC detection and overcome the low-throughput limitation of single-cell DNA sequencing, Wang et al. performed single-cell CNV profile analysis combined with a cellular marker hexokinase 2 (HK2) to detect a total of 385 UETCs from eight urothelial carcinoma patients (Wang et al., 2020).