Low nucleosome occupancy that corresponds to large nucleosome-free regions were detected at TSSs of CDT1, CRLS1, and SNX13 in chronic myelogenous leukemia cells, and at TSSs of POC1A, and CRLS1in breast adenocarcinoma cells. The gene discussed is POC1A; the disease is chronic myelogenous leukemia, BCR-ABL1 positive.