Regarding IFNGR1, although the identified variant IFNGR1 c.40G>A/p.(Val14Met) has a relatively high allele population frequency (0.002–0.003) in Europe, it was proven in previous studies to be damaging and was enriched in patients with eczema herpeticum (ADEH+)—a rare and serious skin infection caused by the herpes simplex virus (Gao et al., 2015). Here, ADSS2 is linked to skin infection.