The obtained results rise several topics for further research, including methodological application of WES to identify novel genes for susceptibility to mycobacterial and other infections, experimental and population-based validations of the identified variants and genes, role of oligogenic inheritance in susceptibility to infectious diseases, haploinsufficiency of STAT1 and other MSMD causing genes, relevance of intronic variants, compound heterozygous inheritance of MSMD, etc. Also, CNV and epigenetic modifications that were not tested are assumed for causality in this study and in general. Here, STAT1 is linked to infection.