Of 15 prioritized in this study genes, four genes, namely GBP2, HEATR3, PPP1R9B and KDM6A, exhibited an elevated transcriptional level in whole blood, spleen or EBV-transformed lymphocytes (Supplementary Table S6), thus lending additional support to their role in increasing susceptibility to mycobacterial infections. Here, HEATR3 is linked to mycobacterial infectious disease.