Noteworthy, five variants, namely TYK2 c.2441C>T, TYK2 c.157G>A, IFNGR1 c.40G>A, IL23R c.257G>A, IL12B c.961G>A and IL12RB1 c.16196C>T, have been previously reported in patients with MSMD, but it is unclear whether they are actually connected to the disease (https://www.ncbi.nlm.nih.gov/clinvar/). Here, IL12B is linked to Mendelian susceptibility to mycobacterial diseases.