Both the level of prothrombin time (MD = 0.31; 95% CI: 0.12 to 0.50, P = 0.001; P = 0.23 for heterogeneity) and APTT (MD = 1.95; 95% CI: 1.30 to 2.59, P < 0.00001; P = 0.57 for heterogeneity) were significantly lower in the COVID-19 positive group than the COVID-19 negative group (Table 3). The gene discussed is F2; the disease is COVID-19.