CD2AP and Alzheimer disease: In addition to APOE, several large-scale genome-wide association studies (GWAS) conducted in European populations over the past decade have identified more than 30 common and rare novel AD susceptibility sites, including CD2AP (Bertram et al., 2008; Seshadri et al., 2010; Hollingworth et al., 2011; Lambert and Amouyel, 2011; Naj et al., 2011).