Immunofluorescence analysis was performed and showed that CD2AP colocalized with pTau (CD2AP immunoassay was strongly and positively correlated with Braak neurofibrillary stage), whereas in primary tau lesions [corticobasal ganglia degeneration (CBD), progressive supranuclear palsy (PSP), and pick disease (PiD)] cases had no detectable neuronal CD2AP deposits in the samples. This evidence concerns the gene MAPT and frontotemporal dementia.