In hepatocellular carcinoma, Wilms tumor 1-associating protein (WTAP) is significantly upregulated, and avian erythroblastosis virus E26 (V-Ets) oncogene homolog-1 (ETS1) was identified as the downstream effector of WTAP, suggesting that WTAP-guided m6A modification contributes to the progression of hepatocellular carcinoma via the HuR-ETS1-cyclin dependent kinase inhibitor 1A (p21)/cyclin dependent kinase inhibitor 1B (p27) axis (26). The gene discussed is CDKN1A; the disease is hepatocellular carcinoma.