RIGI and neoplasm: The unshielded 7SL1 activates the retinoic acid-inducible gene 1 protein (RIG-I), a pattern recognition receptor usually reserved for viral infections, to enhance tumor growth, metastasis, and therapy resistance, suggesting that the regulation of RNA unshielding can couple stromal activation with deployment of DAMPs of RNA, which is closely associated with the aggressive features of cancer (35).