In this study, it was demonstrated that triggering of notch receptor 1-MYC proto-oncogene and basic helix-loop-helix (BHLH) transcription factor (MYC) signaling in the stroma of breast cancer results in the activation of Pol III-driven increase in 7SL1, which is normally shielded by SRP9 and SRP 14 (35). The gene discussed is MYC; the disease is breast cancer.