It is believed that occurrences of EGFR vIII reflect an increase in glioma heterogeneity, which is more common in advanced gliomas and can promote angiogenesis (20, 21), whereas wild-type EGFR gene amplification occurs in all stages of gliomas and can greatly promote invasion and proliferation instead of having effects on angiogenesis (18). This evidence concerns the gene EGFR and central nervous system cancer.