When Twist1 is methylated by SETD6 (a methyltransferase), it will increase the occupancy of EZH2 (a histone lysine methyltransferase) and the catalysis of the repressive H3K27Me3 (histone H3 lysine 27 trimethylation) mark at the locus of lncRNA LINC-PINT (a tumor repressor in gliomas). Here, SETD6 is linked to central nervous system cancer.