A study of NER gene expression levels in the peripheral blood lymphocytes of 483 subjects (251 HNSCC patients and 232 HC) found that XPA and XPB expression levels in HNSCC patients were significantly lower than those in the controls, and lower XPB gene expression levels were associated with an increased risk of HNSCC (35). Here, ERCC3 is linked to head and neck squamous cell carcinoma.