To date, the importance of TGFβ-1 in the resistance process to PDT in NMSC cells has been demonstrated, as CAFs induce tumor progression and tumor promotion by IL1β after PDT, avoiding physical contact between T cells and cancer cells by CXCL12 after PDT, or showing how high dose of PDT suppress macrophages activity. Here, CXCL12 is linked to neoplasm.