The TME is synergistically reprogrammed by TAM-targeting depletion and hypoxia relief, which simultaneously reduces tumor cell PD-L1 expression, decreases the levels of immunosuppressive cytokines like IL-10 and TGF-b, increases the expression of immunostimulatory IFN-γ, improves cytotoxic T lymphocyte (CTL) response, and triggers a strong memory response (120). This evidence concerns the gene CD274 and neoplasm.