GPBAR1 and pancreatic adenocarcinoma: Besides, we also explored the correlation between TGR5 expression, microsatellite instability, and tumor mutational burden (TMB) across all tumors of TCGA; there is a negative correlation between TGR5 expression and tumor matrisome index (TMI) in ovarian serous cystadenocarcinoma (OV) (p = 0.019), pancreatic adenocarcinoma (PAAD) (p = 0.0042), STAD (p < 0.001), and COAD (p = 0.004) (Supplement Figure S7D).