Second, we explore the EPIC, MCPCOUNTER, XCELL, TIDE, CIBEREORT, and CIBEREORT-ABS algorithms to investigate T-cell CD4+, cancer-associated fibroblasts, T-cell CD8+, T-cell regulators, and macrophages (Figure 6B and Supplement Figures S8A, S9A, S10A and S11A). This evidence concerns the gene CD8A and cancer.