CD274 and head and neck squamous cell carcinoma: A combination of nanosatellite vaccine with anti-PD-L1 significantly expands cytotoxic T lymphocytes tumor-specific and limits the populations expressing markers for exhaustion, resulting in more effective tumor control and improved survival (178).Mesoporous silica rods (MSRs) based vaccines were utilized to demonstrate the impact of immunogenic viral antigens on anti-tumor response and immune editing in MOC2-E6E7, a preclinical model of HNSCC which expresses HPV-16 E6 and E7 oncoproteins.