In order to study the effect of vaccine-induced immunologic targeting on the progression of viral-associated HNSCC, single (gp100) and multiple (B16-tumor lysate containing gp100) immunogenic viral antigens were encapsulated within differing molecular weight poly (lactic-co-glycolic acid) (PLGA) nanoparticles (177). Here, PMEL is linked to head and neck squamous cell carcinoma.