CD4 and neoplasm: Iron oxide nanoparticles also can simultaneously promote the reprogramming of tumor-associated macrophages to a pro-inflammatory profile and effectively deliver the ovalbumin antigen (OVA) to dendritic cells and activate both CD4+ and CD8+ antigen-specific T effector cells is achieved for powerful antitumor effects in female C57/BL6 mice injected with EG7-OVA cells (mouse lymphoma cell line) (157, 158).